Activity and interaction of trimethoprim and sulphamethoxazole against Escherichia coli.

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منابع مشابه

Activity and interaction of trimethoprim and sulphamethoxazole against Escherichia coli.

The activity of trimethoprim (TMP) and sulphamethoxazole (SMX), alone and in combination, against a sensitive strain of Escherichia coli was investigated in turbidimetric systems. In a static system in which the conditions of exposure of bacteria to drug resembled those of conventional minimum inhibitory concentration (MIC) titrations, both TMP and SMX exhibited antibacterial activity at concen...

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Synergistic activity of gentamicin with trimethoprim or sulfamethoxazole-trimethoprim against Escherichia coli and Klebsiella pneumoniae.

The effect of combinations of gentamicin with trimethoprim or sulfamethoxazole-trimethoprim against clinical isolates of Escherichia coli (11 strains) and Klebsiella pneumoniae (12 strains) was examined by using a microdilution checkerboard technique. All isolates were susceptible to each antimicrobial agent. Synergism, defined as at least a 2-log(2)-dilution lowering of the minimal inhibitory ...

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Esch. coli endocarditis successfully treated with oral trimethoprim and sulphamethoxazole.

A 42-year-old patient was successfully treated for subacute bacterial endocarditis due to Esch. coli with oral trimethoprim and sulphamethoxazole. The treatment lasted nine months and was continued through a period of cholestatic jaundice superimposed on hepatic damage due to subacute bacterial endocarditis. There were no toxic effects attributable to the two antibacterials despite their prolon...

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Treatment of chancroid. A comparison of sulphamethoxazole and trimethoprim-sulphamethoxazole.

Since sulphonamides are no longer predictably effective in the treatment of chancroid the combination of trimethoprim-sulphamethoxazole (TMP-SMX) was evaluated to identify other effective regimens. One hundred and nine patients with genital ulcers (75 men and 34 women) seen at the Special Treatment Clinic in Nairobi, Kenya, were randomly assigned to treatment with a seven day course of either s...

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Effect of thymidine on activity of trimethoprim and sulphamethoxazole.

Thymidine at levels as low as 0.05 mg/1 reduces the activities of sulphamethoxazole and trimethoprim and their combination in vitro. Using a biological assay procedure, levels of thymidine greater than this were interpreted as being present in urine. The addition of sulphamethoxazole and trimethoprim, singly or in combination, to urine obtained from patients with urinary tract infections showed...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1976

ISSN: 0021-9746

DOI: 10.1136/jcp.29.2.162